ADVERSE PHYSICAL EFFECTS OF ANTIRETROVIRAL THERAPY AND METHADONE ON PEOPLE LIVING WITH HIV/AIDS (PLWHA) USING INJECTION DRUGS (IDUS)
DOI:
https://doi.org/10.53625/ijss.v2i5.4933Keywords:
Adverse Physical Effects, Antiretroviral Therapy, Methadon, PLWHAAbstract
Background: People with HIV who use injecting drugs besides taking ARVs also use methadone. With these conditions, of course there will be a risk of causing various side effects. Based on this, researchers are interested in exploring the physical side effects experienced by PLWHA IDUs while using ARV therapy and Methadone. Method: This qualitative research uses a phenomenological study approach. Participants were taken based on criteria referring to the purposive sampling technique (snowball sampling). Participants were PLWHA with a history of injecting drug users (IDU) aged 20 years and over and had undergone ARV therapy and Methadone maintenance therapy for at least 6 months. Researchers conducted semi-structured in-depth interviews and used Colaizzi's data analysis stages. Results: HIV AIDS sufferers who inject drug users experience physical side effects on the digestive system, namely tooth decay, constipation, anorexia. Side effects on the musculoskeletal system include muscle pain and weakness and insomnia. Side effects of the covering system are the appearance of itching and rashes. Side effect on the reproductive system is a decrease in sexual function. Recommendation: The results of this study need to be followed up with studies with a larger number of participants so that they can represent other problems experienced by PLWHA while using ARV therapy and methadone together.
References
Andrew Carr., David A Cooper. 2000. Adverse effects of antiretroviral therapy. The lancet. Vol 356: 1423-1430.
Bracken. B., George Trksak. 2012. Response inhibition and psychomotor speed during methadone maintenance: impact of treatment duration, dose, and sleep derivation. Psycholgy Medicine Drug and Alcohol dependence. 125; 132.
Bethany J. Heaton, et al. 2022. Exposure of human immune cells, to the antiretrovirals efavirenz and lopinavir, leads to lower glucose uptake and altered bioenergetic cell profiles through interactions with SLC2A1. Biomedicine & Pharmacotegapy Journal. 150 (2022) 112999: 1-14.
Emanuel Krebs, et. Al., 2022. The effect of a methadone reformulation on opioid agonist treatment outcomes: A population-based study in British Columbia, Canada, 2013–14. Journal of Substance Abuse Treatmen. 138 (2022) 108714: 1-9.
Gavin Bart, et al., 2021. Effect of HIV, antiretrovirals, and genetics on methadone pharmacokinetics: Results from the methadone antiretroviral pharmacokinetics study. Drug and Alcohol Dependence. 227: 1-6.
Hirofumi Fukuda et al. 2022. A case of successful treatment with antiretroviral therapy for HIV in a patient with marked liver dysfunction. Helyon Journal. 8 (2022) e11550. 1-4.
L. Nicholls, L. Bragaw, Ch. Ruetsc, Opioid dependence treatment and guidelines, J. Manag. Care Pharm. 16 (2010) 14–21.
Piotr Łój et al, 2014. Adverse drug reactions of antiretroviral therapy in patients receiving methadone substitution treatment. HIV & AIDS review. 13 92014): 14-17.
UNAIDS. 2021. United Nations Programme on HIV/AIDS data 2021, UNAIDS org. Geneva Switzerland.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Idramsyah Idramsyah, Anditha Ratnadhiyani, Sahran Sahran

This work is licensed under a Creative Commons Attribution 4.0 International License.